HIV Coinfection Enhances Complement Activation During Sepsis
نویسندگان
چکیده
منابع مشابه
Complexity of complement activation in sepsis
The complement system is one of the key players in the defence against infections. Its activation during the innate immune response leads to the generation of several proteins that contribute to the lysis and opsonization of microorganisms, regulate inflammatory reactions and bridge innate immunity with the subsequent adaptive immune response. Complement is also activated in overwhelming bacter...
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In hemodialysis using 3 types of dialysis membrane materials [regenerated cellulose (RC), cellulose triacetate (CTA), and polysulfone (PS)], activation of the complement, reduction of white blood cells, and variation of vitronectin (VN) were observed. RC membrane caused a significant reduction of white blood cells and elevations of Bb and soluble membrane attack complex (S-MAC), indicating a st...
متن کاملMonocyte Activation in HIV/HCV Coinfection Correlates with Cognitive Impairment
Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) challenges the immune system with two viruses that elicit distinct immune responses. Chronic immune activation is a hallmark of HIV infection and an accurate indicator of disease progression. Suppressing HIV viremia by antiretroviral therapy (ART) effectively prolongs life and significantly improves immune function....
متن کاملComplement activation in emergency department patients with severe sepsis.
OBJECTIVES This study assessed the extent and mechanism of complement activation in community-acquired sepsis at presentation to the emergency department (ED) and following 24 hours of quantitative resuscitation. METHODS A prospective pilot study of patients with severe sepsis and healthy controls was conducted among individuals presenting to a tertiary care ED. Resuscitation, including antib...
متن کاملHiv/hcv Coinfection
Gazeta Médica da Bahia 2009;79 (Supl.2):24-27 © 2009 Gazeta Médica da Bahia. Todos os direitos reservados. Epidemiology Around one third of HIV patients worldwide suffer from chronic hepatitis C (HCV). HIV and HCV are transmitted by percutaneous exposure to contaminated blood, through sexual intercourse, and to a lesser extent, from mother to infant. The prevalence of HCV infection varies with ...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 2015
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiv074